The insufficiency leads to diabetes, which results in increased glucose levels in the blood (hyperglycaemia) and appearing glucose in the urine (glucosuria). The disease represents a complex metabolism disturbance, although there is disturbance of glucose metabolisms. It appears as a consequence from insufficient secretion or reduced activity of insulin. The signs of diabetes are frequent and intensive passing urine. The urine is bright and glutinous. There is dryness of the mouth thirst, increased appetite, and lost of body weight. Although increased eating. The work ability of patients decreases. The sleeping has disturbance. They are relaxed, skin and mucosa are dry.